Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC052
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-08 16:35
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient tbl Madopar 250mg 4x1/4

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.65 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.65 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 33, 'TN': 25, 'TP': 9, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 16, 'TP': 22, 'FP': 14}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 27, 'TN': 23, 'TP': 15, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 40, 'TN': 28, 'TP': 2, 'FP': 2}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 15.624
timePerCircleCoV 0.172689
timePerCircleSlope -0.0390386
meanError 2.56337
tremorFreq 6.93359
tremorRelPower 36.8913
tremorGyroAmpMean 0.0329152
tremorGyroAmpSlope -0.000937968
tremorGyroAmpCoV 0.376987
tremorCoordAmpMean 0.0665688
tremorCoordAmpSlope -0.000349702
tremorCoordAmpCoV 0.417703
tremorAccAmpMean 0.0521045
tremorAccAmpSlope -0.000409967
tremorAccAmpCoV 0.415915
tremorPcRelVar 0.719838
tremorPcX 0.127108
tremorPcY -0.991889

Circle Segment 1

Duration 16.6 s, Accuracy Estimate 2.589 (lower is better)

Circle Segment 2

Duration 19.0 s, Accuracy Estimate 2.346 (lower is better)

Circle Segment 3

Duration 16.72 s, Accuracy Estimate 2.634 (lower is better)

Circle Segment 4

Duration 16.56 s, Accuracy Estimate 2.74 (lower is better)

Circle Segment 5

Duration 20.16 s, Accuracy Estimate 2.501 (lower is better)

Circle Segment 6

Duration 12.76 s, Accuracy Estimate 2.48 (lower is better)

Circle Segment 7

Duration 13.04 s, Accuracy Estimate 3.111 (lower is better)

Circle Segment 8

Duration 15.16 s, Accuracy Estimate 2.164 (lower is better)

Circle Segment 9

Duration 14.32 s, Accuracy Estimate 2.145 (lower is better)

Circle Segment 10

Duration 11.92 s, Accuracy Estimate 2.924 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 57.28
timePerSpiralCoV 0.186026
timePerSpiralSlope -0.0869413
meanError 4.39467
tremorFreq 6.34766
tremorRelPower 45.9991
tremorGyroAmpMean 0.0900341
tremorGyroAmpSlope 0.00113679
tremorGyroAmpCoV 0.486037
tremorCoordAmpMean 0.0981353
tremorCoordAmpSlope 0.00126934
tremorCoordAmpCoV 0.486785
tremorAccAmpMean 0.0917228
tremorAccAmpSlope 0.000779967
tremorAccAmpCoV 0.367782
tremorPcRelVar 0.734607
tremorPcX 0.645175
tremorPcY -0.764035

Spiral Segment 1

Duration 66.72 s, Accuracy Estimate 4.28 (lower is better)

Spiral Segment 2

Duration 67.36 s, Accuracy Estimate 5.234 (lower is better)

Spiral Segment 3

Duration 46.68 s, Accuracy Estimate 3.981 (lower is better)

Spiral Segment 4

Duration 60.28 s, Accuracy Estimate 3.656 (lower is better)

Spiral Segment 5

Duration 45.36 s, Accuracy Estimate 4.823 (lower is better)

Elel

eDurationMean 0.483947
eDurationStd 0.1501
eDurationStdnorm 0.310157
eDurationMedian 0.4625
eDurationQuartdelta 0.19
eDurationQuartdeltanorm 0.410811
eDurationKurt 2.84259
eDurationTrenddiff -0.105
eDurationTrendratio 0.792079
eWidthMean 5.02484
eWidthStd 1.91362
eWidthStdnorm 0.380832
eWidthMedian 5.031
eWidthQuartdelta 2.808
eWidthQuartdeltanorm 0.55814
eWidthKurt 3.00031
eWidthTrenddiff -0.117
eWidthTrendratio 0.976744
eHeightMean 8.658
eHeightStd 4.2842
eHeightStdnorm 0.494825
eHeightMedian 8.19
eHeightQuartdelta 7.488
eHeightQuartdeltanorm 0.914286
eHeightKurt 1.81503
eHeightTrenddiff -3.159
eHeightTrendratio 0.678571
eAspectMean 0.676594
eAspectStd 0.30683
eAspectStdnorm 0.453493
eAspectMedian 0.576412
eAspectQuartdelta 0.52671
eAspectQuartdeltanorm 0.913774
eAspectKurt 2.38305
eAspectTrenddiff 0.0139373
eAspectTrendratio 1.02439
eSlantMean 0.072878
eSlantStd 0.386004
eSlantStdnorm 5.29658
eSlantMedian 0.0179196
eSlantQuartdelta 0.463265
eSlantQuartdeltanorm 25.8525
eSlantKurt 5.14126
eSlantTrenddiff 0.135714
eRtopMean 0.63439
eRtopStd 0.243208
eRtopStdnorm 0.383374
eRtopMedian 0.717803
eRtopQuartdelta 0.438947
eRtopQuartdeltanorm 0.611515
eRtopKurt 2.00592
eRtopTrenddiff 0.133838
eRbotMean 0.619159
eRbotStd 0.282974
eRbotStdnorm 0.45703
eRbotMedian 0.596296
eRbotQuartdelta 0.44837
eRbotQuartdeltanorm 0.751926
eRbotKurt 2.18016
eRbotTrenddiff -0.167877
eRrightMean 0.75637
eRrightStd 0.221245
eRrightStdnorm 0.29251
eRrightMedian 0.810777
eRrightQuartdelta 0.163685
eRrightQuartdeltanorm 0.201887
eRrightKurt 11.0434
eRrightTrenddiff -0.00557846
eRleftMean 0.411201
eRleftStd 0.19548
eRleftStdnorm 0.475387
eRleftMedian 0.404697
eRleftQuartdelta 0.320603
eRleftQuartdeltanorm 0.792204
eRleftKurt 2.07924
eRleftTrenddiff -0.207457
lDurationMean 0.60859
lDurationStd 0.104308
lDurationStdnorm 0.171393
lDurationMedian 0.61
lDurationQuartdelta 0.13625
lDurationQuartdeltanorm 0.223361
lDurationKurt 3.08195
lDurationTrenddiff -0.125
lDurationTrendratio 0.807692
lWidthMean 9.522
lWidthStd 2.04007
lWidthStdnorm 0.214248
lWidthMedian 9.126
lWidthQuartdelta 2.6325
lWidthQuartdeltanorm 0.288462
lWidthKurt 2.69127
lWidthTrenddiff 1.404
lWidthTrendratio 1.16
lHeightMean 25.968
lHeightStd 3.62809
lHeightStdnorm 0.139714
lHeightMedian 26.676
lHeightQuartdelta 4.7385
lHeightQuartdeltanorm 0.177632
lHeightKurt 2.79878
lHeightTrenddiff 0.819
lHeightTrendratio 1.03125
lAspectMean 0.369363
lAspectStd 0.0708643
lAspectStdnorm 0.191855
lAspectMedian 0.369942
lAspectQuartdelta 0.100198
lAspectQuartdeltanorm 0.270849
lAspectKurt 3.17842
lAspectTrenddiff -0.0177975
lAspectTrendratio 0.952443
lSlantMean -0.0360805
lSlantStd 0.139725
lSlantStdnorm -3.8726
lSlantMedian -0.0165746
lSlantQuartdelta 0.169729
lSlantQuartdeltanorm -10.2403
lSlantKurt 2.87725
lSlantTrenddiff 0.128735
lRtopMean 0.71611
lRtopStd 0.142615
lRtopStdnorm 0.199152
lRtopMedian 0.744444
lRtopQuartdelta 0.179841
lRtopQuartdeltanorm 0.241578
lRtopKurt 2.97004
lRtopTrenddiff 0.163851
lRbotMean 0.827889
lRbotStd 0.258977
lRbotStdnorm 0.312816
lRbotMedian 0.807692
lRbotQuartdelta 0.323613
lRbotQuartdeltanorm 0.400664
lRbotKurt 2.27492
lRbotTrenddiff -0.201389
lRrightMean 0.856741
lRrightStd 0.10993
lRrightStdnorm 0.128312
lRrightMedian 0.877193
lRrightQuartdelta 0.0860408
lRrightQuartdeltanorm 0.0980865
lRrightKurt 9.1626
lRrightTrenddiff 0.0718271
lRleftMean 0.502041
lRleftStd 0.124503
lRleftStdnorm 0.247994
lRleftMedian 0.517544
lRleftQuartdelta 0.185735
lRleftQuartdeltanorm 0.358877
lRleftKurt 1.97485
lRleftTrenddiff -0.146881

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.376575
sumTouchScores 4.14233
meanMovementTime 1.6855
numTouches 11
undershootPercentage 9.09091
overshootPercentage 45.4545

FITTS Long Modified

meanTouchScore 0.584367
sumTouchScores 4.67494
meanMovementTime 2.08214
numTouches 8
undershootPercentage 12.5
overshootPercentage 50

ZigZag

numZigzags 5
timePerZigzagMean 29.064
timePerZigzagCoV 0.0385921
timePerZigzagSlope 0.0100468
meanError 1.99608
tremorFreq 6.64062
tremorRelPower 48.5591
tremorGyroAmpMean 0.0876144
tremorGyroAmpSlope -2.6624e-05
tremorGyroAmpCoV 0.448979
tremorCoordAmpMean 0.141223
tremorCoordAmpSlope -0.000417284
tremorCoordAmpCoV 0.408154
tremorAccAmpMean 0.102218
tremorAccAmpSlope -0.000194461
tremorAccAmpCoV 0.311067
tremorPcRelVar 0.838552
tremorPcX 0.0805524
tremorPcY 0.99675

ZigZag Segment 1

Duration 28.64 s, Accuracy Estimate 2.292 (lower is better)

ZigZag Segment 2

Duration 28.68 s, Accuracy Estimate 1.783 (lower is better)

ZigZag Segment 3

Duration 29.72 s, Accuracy Estimate 2.056 (lower is better)

ZigZag Segment 4

Duration 27.68 s, Accuracy Estimate 1.824 (lower is better)

ZigZag Segment 5

Duration 30.6 s, Accuracy Estimate 2.026 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 16.0933
timePerZigzagCoV 0.277681
timePerZigzagSlope -0.0782578
zigzagHeightMean 71.168
zigzagHeightCoV 0.045213
zigzagHeightSlope 0.0114402
meanError 0.0630061
tremorFreq 6.93359
tremorRelPower 52.5611
tremorGyroAmpMean 0.0712906
tremorGyroAmpSlope -0.00201804
tremorGyroAmpCoV 0.631816
tremorCoordAmpMean 0.168577
tremorCoordAmpSlope -0.00119287
tremorCoordAmpCoV 0.757127
tremorAccAmpMean 0.0930975
tremorAccAmpSlope -0.000678003
tremorAccAmpCoV 0.500314
tremorPcRelVar 0.866855
tremorPcX -0.0272987
tremorPcY -0.999627

ZigZag Offset Segment 1

Duration 16.44 s, Accuracy Estimate 0.103 (lower is better)

ZigZag Offset Segment 2

Duration 24.8 s, Accuracy Estimate 0.104 (lower is better)

ZigZag Offset Segment 3

Duration 13.0 s, Accuracy Estimate 0.046 (lower is better)

ZigZag Offset Segment 4

Duration 15.08 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 5

Duration 12.88 s, Accuracy Estimate 0.052 (lower is better)

ZigZag Offset Segment 6

Duration 14.36 s, Accuracy Estimate 0.047 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.61}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.65}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7835243098113704}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8884878775705518}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4877726555217643}